Donohue syndrome

noun

Don·​o·​hue syndrome ˈdän-ə-ˌhyü- 

variants also Donohue's syndrome

: a rare hereditary disorder of extreme insulin resistance that is characterized especially by intrauterine and postnatal growth retardation, skin abnormalities, hirsutism, emaciation, widely spaced eyes, thick lips, low-set ears, and enlarged genitalia and is usually fatal during early infancy : leprechaunism

Note: Donohue syndrome is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.